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中国癌症防治杂志

中国癌症防治杂志 ›› 2013, Vol. 5 ›› Issue (2): 148-151.doi: 10.3969/j.issn.1674-5671.2013.02.16

• 临床研究 • 上一篇    下一篇

放化疗联合热疗治疗鼻咽癌颈部淋巴结转移的疗效

  

  • 出版日期:2013-06-25 发布日期:2013-06-27
  • 通讯作者: 王仁生 E-mail:wrsgx@yahoo.com.cn
  • 基金资助:

    广西医疗卫生重点科研课题（重 200626）

Combined therapy of chemotherapy-radiotherapy-hyperthermia to treat nasopharyngeal carcinoma with cervical lymph node metastasis

广西医科大学第一附属医院放疗科   

  • Online:2013-06-25 Published:2013-06-27

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被引次数

6

摘要： 目的 观察放化疗联合热疗治疗鼻咽癌颈部淋巴结转移的疗效。方法 将203例初治的鼻咽癌颈部淋巴结转移患者随机分为对照组（98例）和热放组（105例）。对照组接受5-氟尿嘧啶+顺铂诱导化疗后对鼻咽原发灶和颈部淋巴结转移灶予以常规放疗。热放组放化疗方法同对照组，颈部淋巴结转移灶于放疗第1 周开始配合局部热疗。结果 热放组和对照组治疗后3个月颈部淋巴结转移灶的完全消退率分别为81.0%和62.2%（P<0.05），5 年无瘤生存率分别为51.4%和20.4%（P<0.05），3年生存率和5 年生存率分别为76.2%、52.0%和58.1%、40.8%（P均<0.05）。两组湿性皮炎的发生率分别为5.7%和3.1%（P>0.05）。结论 放化疗联合热疗治疗鼻咽癌颈部淋巴结转移的近期疗效、远期疗效均优于单纯放化疗。

关键词: 鼻咽肿瘤, 淋巴结转移, 放疗, 化疗, 热疗, 疗效

Abstract: Objective To evaluate the effect of combined chemotherapy-radiotherapy-hyperthermia on patients with nasopharyngeal carcinoma and cervical lymph node metastasis. Methods A total of 203 cases of nasopharyngeal carcinoma with cervical lymph node metastasis were randomly divided into two groups：the control group（98 cases），which was treated with  combined 5-fluorouracil and cisplatin chemotherapy，as well as routine radiotherapy； and the hyperthermia group（105 cases），which was treated with the same chemo- and radiotherapy as the control group to treat nasopharyngeal carcinoma，while cervical lymph node metastasis was treated with hyperthermia accompanied by radiotherapy. Results Complete response rates of cervical lymph nodes were 62.2% in the control group and 81.0%  in the hyperthermia group（P<0.05）.The 5 year disease-free survival rates was 20.4% in the control group and 51.4% in the hyperthermia group（P<0.05）.The 3- and 5-year overall survival rate were 52.0% and 40.8% in the control group and 76.2% and 58.1% in the hyperthermia group（P>0.05）. Conclusions The combination of chemotherapy-radiotherapy-hyperthermia is more effective than chemotherapy-radiotherapy for patients with nasopharyngeal carcinoma and cervical lymph node metastasis.

Key words: Nasopharyngeal neoplasms, Lymph node metastasis, Radiotherapy, Chemotherapy, Hyperthermia, Therapeutic effect